æ°ææ€ç©åŠã®é åçãªåéãæ¢æ±ããŸãããã倿§ãªæåãç°å¢ã«ããã人ã ãšæ€ç©ã®é¢ä¿æ§ãç§åŠçã«ç ç©¶ããåŠåã§ãã
æ°ææ€ç©åŠã®ç§åŠïŒäººéãšæ€ç©ã®é¢ä¿ãè§£ãæãã
æ°ææ€ç©åŠã¯ããã®æ žå¿ã«ãããŠã人ã ãšæ€ç©ã®é¢ä¿ãç§åŠçã«ç ç©¶ããåŠåã§ããæ€ç©åŠãšæ°æåŠã®éã®æºãåããåŠéçãªåéã§ãããæ§ã ãªæåãé£ç©ãè¬ãäœå± ãè¡£æãååŒããã®ä»çæŽ»ã®æ§ã ãªåŽé¢ã§æ€ç©ãã©ã®ããã«å©çšããŠããããæ¢æ±ããŸããçç©å€æ§æ§ãæåéºç£ããããŠæç¶å¯èœãªè³æºç®¡çãçè§£ããäžã§æ¥µããŠéèŠãªç ç©¶åéã§ãã
æ°ææ€ç©åŠãšã¯ïŒãã®ç¯å²ãå®çŸ©ãã
ãæ°ææ€ç©åŠããšããèšèã¯ã1895幎ã«ã¢ã¡ãªã«ã®æ€ç©åŠè ãžã§ã³ã»ãŠã£ãªã¢ã ã»ããŒã·ã¥ããŒã¬ãŒã«ãã£ãŠäœãããŸãããåœåã®çŠç¹ã¯ãåã«å äœæ°ææåã«ããæ€ç©å©çšãèšé²ããããšã§ãããããã®åéã¯å€§ããé²åããŸãããçŸä»£ã®æ°ææ€ç©åŠã¯ã以äžãå«ããããåºç¯ã§ç§åŠçãªã¢ãããŒããå å«ããŠããŸãã
- äŒçµ±çç¥èã®èšé²ïŒ æ§ã ãªæåã§å©çšãããŠããç¹å®ã®æ€ç©ãšããã®å©ç𿹿³ãèšé²ããã
- æ€ç©ã®åå®ãšåéïŒ æ€ç©æšæ¬ãæ£ç¢ºã«åå®ããåéããŠãããªãåæã«äŸããã
- ååŠçã»è¬çåŠçåæïŒ æ€ç©ã«å«ãŸããååŠç©è³ªãšãã®æœåšçãªè¬å¹ã調æ»ããã
- çæ åŠçç ç©¶ïŒ æ€ç©ã®æé·ãšååžã«åœ±é¿ãäžããç°å¢èŠå ãçè§£ããã
- ä¿å šæŽ»åïŒ æ€ç©è³æºã®æç¶å¯èœãªå©çšãšä¿å šãä¿é²ããã
- çµæžéçºïŒ æ°ããæ€ç©ç±æ¥ã®è£œåãç£æ¥ãéçºããå¯èœæ§ãæ¢ãã
æ°ææ€ç©åŠã®æŽå²ïŒèгå¯ããç§åŠçæ¢æ±ãž
æ°ææ€ç©åŠã®ã«ãŒãã¯å€ä»£ææã«ãŸã§é¡ãããšãã§ããŸããåæã®äººé¡ã¯çåã®ããã«æ€ç©ã«å€§ããäŸåãããã®å©çšã«é¢ããè€éãªç¥èäœç³»ãç¯ããŸãããè¬çšç®çã§ã®æ€ç©å©çšã®èšŒæ ã¯æ°å幎åã«é¡ããŸããäŸãã°ïŒ
- å€ä»£ãšãžããïŒ ãšãŒãã«ã¹ã»ããã«ã¹ïŒçŽå å1550幎é ïŒã«ã¯ãè¬çšç®çã§ã®æ§ã ãªæ€ç©ã®å©çšãèšé²ãããŠããŸãã
- å€ä»£ã®ãªã·ã£ïŒ ãæ€ç©åŠã®ç¶ããšèŠãªãããããªãã©ã¹ãã¹ïŒçŽå å371-287幎é ïŒã¯ããã®èäœã§å€ãã®æ€ç©ã®è¬å¹ãèšè¿°ããŸããã
- å€ä»£äžåœïŒ ç¥èŸ²æ¬èçµïŒçŽå 1äžçŽé ïŒã¯ãæ°çŸçš®é¡ã®æ€ç©ã®è¬çšå©çšã詳述ããå æ¬çãªè¬å±æ¹ã§ãã
å€§èªæµ·æä»£ããšãŒãããã®æ¢æ€å®¶ãåç©åŠè ã¯ãæ°ãã«çºèŠãããåå°ã®å äœæ°æã«ããæ€ç©å©çšãèšé²ãå§ããŸããããããããããã®åæã®èšé²ã¯èšè¿°çã§ããããšãå€ããå³å¯ãªç§åŠçåæãæ¬ ããŠããŸãããæ°ææ€ç©åŠã®åéã¯ãã¢ã¡ãªã«å€§éžã«ããããæ°ææ€ç©åŠã®ç¶ããšèŠãªããããªãã£ãŒãã»ãšãŽã¡ã³ãºã»ã·ã¥ã«ãã¹ã®ãããªæ€ç©åŠè ã®ç ç©¶ã«ããã20äžçŽã«å¢ããå¢ããŸãããã·ã¥ã«ãã¹ã¯ãã¢ããŸã³ã®ç±åž¯éšæã®å äœæ°ææåã«ãã粟ç¥äœçšæ§æ€ç©ã®å©çšãæ°å幎ã«ããã£ãŠç ç©¶ããæ€ç©ç±æ¥ã®è¬ãæåçæ £ç¿ã«é¢ããæã ã®çè§£ã«å€§ããè²¢ç®ããŸããã
æ°ææ€ç©åŠã®æ¹æ³è«ïŒåŠéçã¢ãããŒã
æ°ææ€ç©åŠã®ç ç©¶ã§ã¯ã以äžãå«ãæ§ã ãªåéã®ææ³ãçšããããŸãã
æ°æèªåŠçãã£ãŒã«ãã¯ãŒã¯
ããã¯ãç¹å®ã®æåã«èº«ã眮ãããã®æ€ç©ã«é¢ããç¥èãåŠã¶ããšãå«ã¿ãŸããäž»ãªææ³ã«ã¯ä»¥äžããããŸãã
- åäžèгå¯ïŒ ã³ãã¥ããã£ã®äžã§ç掻ãã圌ãã®æ¥åžžæŽ»åã«åå ããŠçŽæ¥çãªçµéšãåŸãã
- ã€ã³ã¿ãã¥ãŒïŒ äž»èŠãªæ å ±æäŸè ã«å¯ŸããŠæ§é åããã³åæ§é åã€ã³ã¿ãã¥ãŒãè¡ããæ€ç©ã®å©çšæ³ãèª¿çæ³ãæåçæçŸ©ã«é¢ããè©³çŽ°ãªæ å ±ãåéããã
- ãã©ãŒã«ã¹ã°ã«ãŒãïŒ ã°ã«ãŒããã£ã¹ã«ãã·ã§ã³ãä¿é²ããæ€ç©è³æºã«é¢ããå ±æãããç¥èãèŠç¹ãæ¢ãã
- æ°ææ€ç©åŠç調æ»ïŒ ã³ãã¥ããã£ã§å©çšãããŠããæ€ç©ããçŸå°ã®åç§°ãçšéãèª¿çæ³ãå«ããŠäœç³»çã«èšé²ããã
æ€ç©ã®åéãšåå®
æ€ç©æšæ¬ãåéããããšã¯ãæ°ææ€ç©åŠçç ç©¶ã«ãããŠéèŠãªã¹ãããã§ããåéãããæ€ç©ã¯ãåé¡ããŒãæ€ç©æšæ¬é€šãå°éå®¶ã®å©èšãçšããŠæ éã«åå®ãããŸããèšŒæ æšæ¬ã¯ãç ç©¶ã®æ°žä¹ çãªèšé²ãæäŸããå°æ¥ã®æ€èšŒãå¯èœã«ããããã«æ€ç©æšæ¬é€šã«å¯èšãããŸãã
ååŠçã»è¬çåŠçåæ
ããã¯ãæ€ç©ã®ååŠçµæãåæããŠæŽ»æ§ååç©ãç¹å®ãããã®æœåšçãªè¬ç广ã調æ»ããããšãå«ã¿ãŸããäžè¬çãªææ³ã«ã¯ä»¥äžããããŸãã
- æœåºïŒ æ§ã ãªæº¶åªãçšããŠæ€ç©ææããååŠç©è³ªãåé¢ããã
- ã¯ãããã°ã©ãã£ãŒïŒ ã¬ã¹ã¯ãããã°ã©ãã£ãŒè³ªéåææ³ïŒGC-MSïŒãé«éæ¶²äœã¯ãããã°ã©ãã£ãŒïŒHPLCïŒãªã©ã®æè¡ãçšããŠåã ã®ååç©ãåé¢ã»åå®ããã
- ãã€ãªã¢ãã»ã€ïŒ æ€ç©æœåºç©ãåé¢ãããååç©ã®çç©æŽ»æ§ãin vitroïŒè©Šéšç®¡å ïŒããã³in vivoïŒçäœå ïŒã§è©Šéšããã
çæ åŠçç ç©¶
æ€ç©å©çšã®çæ åŠçæèãçè§£ããããšã¯ãæç¶å¯èœãªè³æºç®¡çã«ãšã£ãŠäžå¯æ¬ ã§ããçæ åŠçç ç©¶ã«ã¯ä»¥äžãå«ãŸããå ŽåããããŸãã
- æ€ç調æ»ïŒ ç¹å®ã®å°åã®æ€ç©çš®ã®æ§æãšè±å¯ããè©äŸ¡ããã
- è³æºè©äŸ¡ïŒ ã³ãã¥ããã£ã§å©çšãããŠããæ€ç©è³æºã®å©çšå¯èœæ§ãšæç¶å¯èœæ§ãè©äŸ¡ããã
- 圱é¿è©äŸ¡ïŒ æ€ç©ã®åç©«ããã®ä»ã®äººé掻åãçæ ç³»ã«äžãã圱é¿ã調æ»ããã
æ°ææ€ç©åŠã®å®è·µïŒäžçäžã®äºäŸ
æ°ææ€ç©åŠã®ç ç©¶ã¯ãäžçäžã®äººã ãæ€ç©ãå©çšãã倿§ãªæ¹æ³ã«ã€ããŠè²ŽéãªæŽå¯ããããããŠããŸãããããã«ããã€ãã®äŸãæããŸãã
ã¢ããŸã³ç±åž¯éšæïŒäŒçµ±çç¥èã®å®åº«
ã¢ããŸã³ç±åž¯éšæã«ã¯ãå€çš®å€æ§ãªæ€ç©çš®ãšããã®å©çšã«é¢ããåºç¯ãªç¥èãæã€å äœæ°ææåãååšããŸããäŸãã°ïŒ
- ã¢ã€ã¯ã¹ã«ïŒ å€ãã®å äœæ°æã°ã«ãŒãã粟ç¥çããã³è¬çšç®çã§äœ¿çšãã粟ç¥äœçšæ§ã®é£²ã¿ç©ãéåžžãBanisteriopsis caapiãšããã€ãæ€ç©ãšPsychotria viridisã®èãå«ãŸããŸãã
- ã¯ã©ãŒã¬ïŒ æ§ã ãªæ€ç©çš®ããåŸãããæ¯ã§ãå äœæ°ã®ç©äººãç²ç©ã麻çºãããããã«äœ¿çšããŸãã
- è¬çšæ€ç©ïŒ å äœæ°ã®æ²»çåž«ã¯ããã©ãªã¢ãææçãç®èç ãªã©ãæ§ã ãªç æ°ãæ²»çããããã«åºç¯å²ã®æ€ç©ã䜿çšããŸãã
äŒçµ±äžåœå»åŠïŒTCMïŒïŒæ²»çãžã®ããªã¹ãã£ãã¯ãªã¢ãããŒã
TCMã¯ãäžåœã§æ°å幎ã«ããã£ãŠå®è·µãããŠããäŒçµ±çãªå»çã·ã¹ãã ã§ããäœå ã®ãã©ã³ã¹ãšèª¿åãåãæ»ãããã«ã挢æ¹è¬ã®å©çšã«å€§ããäŸåããŠããŸããããç¥ãããäŸã«ã¯ä»¥äžããããŸãã
- é«éºäººåïŒ ãšãã«ã®ãŒãé«ããå ç«ã·ã¹ãã ã匷åããèªç¥æ©èœãåäžãããããã«äœ¿çšãããŸãã
- çå§ïŒ åãæ°ãæ¶åäžè¯ãççã®æ²»çã«äœ¿çšãããŸãã
- é»èïŒãªãŠã®ïŒïŒ å ç«ã·ã¹ãã ã匷åããææçããä¿è·ããããã«äœ¿çšãããŸãã
ã¢ãŒãŠã«ãŽã§ãŒãïŒçåœã®ç§åŠ
ã¢ãŒãŠã«ãŽã§ãŒãã¯ãå¿ã身äœã粟ç¥ã®ãã©ã³ã¹ãä¿ã€ããšã®éèŠæ§ã匷調ããã€ã³ãã®äŒçµ±çãªå»çã·ã¹ãã ã§ããããŒãçæ³ã¯ã¢ãŒãŠã«ãŽã§ãŒãæ²»çã®äžå¿çãªåœ¹å²ãæãããŸããäžè¬çãªäŸã«ã¯ä»¥äžããããŸãã
- ã¿ãŒã¡ãªãã¯ïŒãŠã³ã³ïŒïŒ æççãæé žåãæ¶æ¯äœçšã®ããã«äœ¿çšãããŸãã
- ããŒã ïŒ ç®èçŸæ£ãææçãæ¶åäžè¯ã®æ²»çã«äœ¿çšãããŸãã
- ããªãã¡ã©ïŒ 3ã€ã®æç©ïŒã¢ã ã©ãããã¿ããããªã¿ãïŒã®çµã¿åããã§ãè§£æ¯ãä¿é²ããæ¶åãæ¹åããããã«äœ¿çšãããŸãã
åµè¬ã«ãããæ°ææ€ç©åŠã®åœ¹å²
æ°ææ€ç©åŠã®ç ç©¶ã¯ãå€ãã®éèŠãªå»è¬åã®çºèŠã«ãããŠæ¥µããŠéèŠãªåœ¹å²ãæãããŠããŸãããæ€ç©ã®äŒçµ±çãªå©çšæ³ãç ç©¶ããããšã§ãç ç©¶è ã¯ãããªã調æ»ã®ããã®ææãªåè£ãç¹å®ããããšãã§ããŸããããã€ãã®æ³šç®ãã¹ãäŸã«ã¯ä»¥äžããããŸãã
- ãããŒãïŒ ããã®æšã®æš¹ç®ããæœåºããããã©ãªã¢ã®æ²»çã«äœ¿çšãããŸãããã®çºèŠã¯ãåç±³ã®å äœæ°æã«ããããã®æš¹ç®ã®äŒçµ±çãªäœ¿çšã«åºã¥ããŠããŸãã
- ã¢ã¹ããªã³ïŒ ã€ãã®ã®æš¹ç®ã«å«ãŸãããµãªãã«é žã«ç±æ¥ããŸããã€ãã®ã®æš¹ç®ã®è¬å¹ã¯äœäžçŽã«ãããã£ãŠç¥ãããŠããŸããã
- ã¿ããœãŒã«ïŒ ã¿ã€ãã€ãšãŠã€ãã€ã®æš¹ç®ããæœåºãããããã®æ²»çã«äœ¿çšãããŸãããã®çºèŠã¯ãã€ãã€ã®æšãæããååç©ã®æœåšçãªäŸçµŠæºã§ããããšãç¹å®ããæ°ææ€ç©åŠçç ç©¶ã«åºã¥ããŠããŸãã
æ°ææ€ç©åŠãšä¿å šïŒçç©å€æ§æ§ãšæåéºç£ã®ä¿è·
æ°ææ€ç©åŠã¯ãæ€ç©ã®å©çšæ³ãèšé²ããã ãã§ãªããçç©å€æ§æ§ãšæåéºç£ã®ä¿å šãä¿é²ããããšã§ããããŸããå äœæ°æãç°å¢ã«ã€ããŠèç©ããŠããç¥èã§ããäŒçµ±ççæ åŠçç¥èïŒTEKïŒã¯ãæç¶å¯èœãªè³æºç®¡çã«é¢ãã貎éãªæŽå¯ãæäŸããããšãã§ããŸãã
å°åã®ã³ãã¥ããã£ãšååããããšã§ãæ°ææ€ç©åŠè ã¯ä»¥äžã®æ¯æŽãããããšãã§ããŸãã
- çµ¶æ» å±æ§æ€ç©çš®ã®ä¿è·ïŒ çæ¯å°ã®åªå€±ãä¹±ç²ããŸãã¯æ°åå€åã«ãã£ãŠè ããããŠããæ€ç©ãç¹å®ããä¿è·ããã
- æç¶å¯èœãªæ¡éæ¹æ³ã®ä¿é²ïŒ åäœæ°ãæžå°ãããããçæ ç³»ãæãªã£ããããªãæ¹æ³ã§æ€ç©ãæ¡éããããã®ã¬ã€ãã©ã€ã³ãçå®ããã
- äŒçµ±çç¥èã®ä¿åïŒ æ€ç©ã®å©çšæ³ãçæ åŠçé¢ä¿ã«é¢ããå äœæ°æã®ç¥èãèšé²ããä¿åããã
- å°åã³ãã¥ããã£ã®ãšã³ãã¯ãŒã¡ã³ãïŒ å°åã³ãã¥ããã£ãèªãã®å€©ç¶è³æºã管çã»ä¿è·ããåãçµã¿ãæ¯æŽããã
æ°ææ€ç©åŠã®èª²é¡ãšä»åŸã®æ¹åæ§
ãã®éèŠæ§ã«ãããããããæ°ææ€ç©åŠã¯ããã€ãã®èª²é¡ã«çŽé¢ããŠããŸãããããã«ã¯ä»¥äžãå«ãŸããŸãã
- äŒçµ±çç¥èã®åªå€±ïŒ å äœæ°ææåãã°ããŒãã«åãè¿ä»£åã«ãŸããŸãæãããã«ã€ããŠãæ€ç©å©çšã«é¢ããäŒçµ±çç¥èãé©ãã¹ãéãã§å€±ãããŠããŸãã
- ãã€ãªãã€ã©ã·ãŒïŒçç©è³æºã®çè³è¡çºïŒïŒ äŒæ¥ãç ç©¶è ã«ããäŒçµ±çç¥èãæ€ç©è³æºã®ç¡èš±å¯ã®ççšã
- å«ççé æ ®ïŒ æ°ææ€ç©åŠã®ç ç©¶ããå°åã³ãã¥ããã£ã®æš©å©ãšæåç䟡å€ãå°éããå«ççãã€è²¬ä»»ããæ¹æ³ã§å®æœãããããšãä¿èšŒããã
- æ°åå€åïŒ æ°åå€åãæ€ç©ã®ååžãšæ€ç©è³æºã®å©çšå¯èœæ§ã«äžãã圱é¿ã
ãããã®èª²é¡ã«å¯ŸåŠããããã«ãæ°ææ€ç©åŠã¯ä»¥äžã®ããšãè¡ãå¿ èŠããããŸãã
- äŒçµ±çç¥èã®èšé²ãšä¿åãåªå ããã
- äŒçµ±çç¥èãä¿è·ãããã€ãªãã€ã©ã·ãŒãé²ãããã®ãã匷åãªæ³çæ çµã¿ãéçºããã
- å°åã³ãã¥ããã£ã®æš©å©ãšæåç䟡å€ãå°éãããæ°ææ€ç©åŠçç ç©¶ã®ããã®å«çæéãæšé²ããã
- æ°åå€åã®èæ ®ãæ°ææ€ç©åŠçç ç©¶ãšä¿å šæŽ»åã«çµ±åããã
- ãªã¢ãŒãã»ã³ã·ã³ã°ãã²ããã¯ã¹ãªã©ã®æ°æè¡ãåãå ¥ããæ€ç©ã®å€æ§æ§ãšäººéãšæ€ç©ã®çžäºäœçšã«é¢ããçè§£ãæ·±ããã
æ°ææ€ç©åŠïŒäžççã«é¢é£æ§ã®ããåé
æ°ææ€ç©åŠã¯ã人ã ãšæ€ç©ã®éã®è€éã§çžäºã«é¢é£ããé¢ä¿ãçè§£ããããã®ãŠããŒã¯ãªã¬ã³ãºãæäŸããŸããçç©å€æ§æ§ãæåéºç£ãæç¶å¯èœãªéçºããããŠæ°ããå»è¬åããã®ä»ã®æ€ç©ç±æ¥è£œåãçºèŠããå¯èœæ§ã«ã€ããŠè²ŽéãªæŽå¯ããããããŸããæ°åå€åãçç©å€æ§æ§ã®åªå€±ãšãã£ãäžççãªèª²é¡ã«çŽé¢ããäžã§ãæ°ææ€ç©åŠã¯ããã¹ãŠã®äººã ã®å©çã®ããã«æ€ç©è³æºã®æç¶å¯èœãªå©çšãšä¿å šãä¿é²ããäžã§ããŸããŸãéèŠãªåœ¹å²ãæããã§ãããã
èªè ã®ããã®å®è·µçãªæŽå¯
- æ°ææ€ç©åŠç ç©¶ãæ¯æŽããïŒ æ°ææ€ç©åŠã®ç ç©¶ãšä¿å šæŽ»åãæ¯æŽããå£äœãæ¢ããŸããããå¯ä»ããã©ã³ãã£ã¢æŽ»åãæ€èšããŠãã ããã
- äŒçµ±çãªæ€ç©å©çšã«ã€ããŠåŠã¶ïŒ èªåã®å°åãäžçã®ä»ã®å°åã§ã®äŒçµ±çãªæ€ç©ã®å©çšæ³ãæ¢æ±ããŸããããå°å ã®æ€ç©åãåç©é€šãæåã»ã³ã¿ãŒã蚪ããŠãããã«åŠã³ãŸãããã
- äŒçµ±çç¥èãå°éããïŒ äŒçµ±çãªæ€ç©ã®å©çšæ³ã«ã€ããŠåŠã¶éã«ã¯ããã®ç¥èãæã€ã³ãã¥ããã£ã®ç¥èãšæåç䟡å€ãåžžã«å°éããŠãã ããã
- æç¶å¯èœãªæ¡éãä¿é²ããïŒ å人çãªå©çšã®ããã«æ€ç©ãæ¡éããå Žåã¯ãæç¶å¯èœãªæ¹æ³ã§è¡ãããã«ããŠãã ããã責任ããæ¡éã®ã¬ã€ãã©ã€ã³ã«åŸããä¹±ç²ãé¿ããŠãã ããã
- æ€ç©ä¿å šãæå±ããïŒ æ€ç©ã®çç©å€æ§æ§ãä¿è·ããæç¶å¯èœãªè³æºç®¡çãä¿é²ããæ¿çãã€ãã·ã¢ãããæ¯æŽããŠãã ããã
æ°ææ€ç©åŠã«é¢ããããšã§ãç§ãã¡ã¯ç掻ã«ãããæ€ç©ã®éèŠæ§ãããæ·±ãçè§£ããæªæ¥ã®äžä»£ã®ããã«ãã®ä¿å šã«è²¢ç®ããããšãã§ããŸãã